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Clinical trials have demonstrated varying degrees of weight loss depending on the specific agent and dosage: semaglutide 2.4mg (Wegovy) produces approximately 15% weight loss at 68 weeks, liraglutide 3mg (Saxenda) typically achieves 5-8% weight loss, while tirzepatide has shown up to 20% weight reduction in obesity trials

Int J Reprod BioMed

Retatrutide's effect on liver fat emerged as a compelling secondary endpoint in Phase 2, lending the molecule a therapeutic profile that extends well beyond the scale

In a sub-analysis of more than 300 participants from a large clinical trial, individuals regained, on average, two-thirds of the weight they had lost within one year of stopping the medication

2 For those responding well, treatment can continue with ongoing monitoring