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The authors described TB4 as acting through promotion of cell migration, stem cell mobilisation and differentiation, and inhibition of inflammation and apoptosis
Neuigkeiten zu Diabetes und DPP-4-Hemmung
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Initially, main concerns were receptor-activating activity while recently, downstream effects of GLP-1R and GIPR have been more and more revealed that not only receptor activation promotes cAMP and stimulates insulin releasing, but also other factors (-arrestin recruitment, residence time, etc.) influence receptor internalization, which further elicits long-term effects in vivo
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