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The 2026 ADA Standards of Care mark a continued evolution in diabetes pharmacotherapy, more formally incorporating GLP-1 receptor agonists into organ-specific treatment algorithms
Though the study doesn't claim that GLP-1s should purposely be continued during critical illness, it does highlight that GLP-1 agonists have anti-inflammatory effects, improve insulin sensitivity, and reduce glucose variability - factors that may actually be protective during critical illness
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Actin cytoskeletal dynamics required for GLP-1 exocytosis GLP-1 is secreted by enteroendocrine L cells in response to food intake in a calcium-dependent manner 10,11
