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It is important to note that B12 injections should only be used when there is a diagnosed deficiency or clear clinical indication

Persistent numbness or weakness after an injection should always be reviewed by a doctor

NNMT is overexpressed in adipose tissue of obese subjects, and its inhibition has been explored as a strategy to modulate methyl group flux and NAD+ precursor availability

Who Is at Risk of Very High B12 Levels

There are specific scenarios where combining these two forms of B12 might be considered, as part of a tailored treatment plan: Reducing Injection Frequency: For some individuals who require lifelong B12 due to malabsorption but dislike frequent injections, a doctor might explore if high-dose oral supplements can help maintain adequate levels between less frequent injections