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In addition, DMF treatment increased DNA 5hmC but not 5mC levels in the CBS gene promoter CpG island (Fig

C Glutathione v L-Glutathione u l cht chng oxy ha mnh v em li li ch cho sc khe tng t nhau

J Biomed Opt 9, 11981205 (2004)

The pathway leading to the formation of GSH by the action of -glutamylcysteine synthetase (GCS) is blocked by buthionine sulfoximine (BSO), inducing artificial stress condition in dHL60 cells

GSH has long been implicated as a major antioxidant and redox regulator that functions to mitigate and alleviate this oxidative damage ( However, the preceding sections of this paper establish that GSH is not merely a passive antioxidant, but an immune regulator and modulator with actions dependent upon the pathophysiologic context (Ghezzi, 2011) GSH acts to regulate the thresholds necessary for immunologic activation through redox-sensitive signal transduction pathways, influences antigen presentation and the development/differentiation of immune cells, and modulates the production of cytokines