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GLP-1 prescriptions have more than tripled since 2020, and spending on GLP-1 drugs already exceeded $50 billion annually in the US by 2025
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Fat cells release inflammatory mediators known as adipokines , including: Leptin Adiponectin Interleukin-6 Tumor necrosis factor-alpha These mediators contribute to: Cartilage degradation Synovial inflammation Osteophyte formation Because of these mechanisms, obesity is considered one of the most important modifiable risk factors for knee osteoarthritis
Patients miss 2 or more consecutive doses: Inform them to resume dosing as scheduled
After stopping, it takes approximately 30 days (5 half-lives) for 97% of the drug to clear from your body
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