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Gluten and casein-derived molecules, if present in subjects with altered immune system, like in ASD, can cross the highly permeable intestinal barrier, and activate pro-inflammatory processes, releasing pro-inflammatory mediators that travel to the brain centers through the blood, contributing to neuro-inflammatory activities ( 5 Antioxidants targeting oxidative stress and neuroinflammation in ASD Besides excessive levels of oxidative stress and pro-inflammatory molecules, ASD patients are also distinguished for their nutritional deficits

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Abbreviations AS: artesunate CI: combination index DMSO: dimethylsulfoxide iFBS: heat inactivated fetal bovine serum NAC: N-acetylcysteine NTS: newly transformed schistosomula PI: propidium iodide PZQ: praziquantel RESV: resveratrol TEM: transmission electron microscopy References Steinmann P, Keiser J, Bos R, Tanner M, Utzinger J

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