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Receptor binding raises intracellular cyclic AMP through adenylyl cyclase activation, with downstream signalling that includes glucose-dependent insulin secretion, glucagon suppression, gastric-emptying delay, central appetite modulation, and adipose-tissue-related effects (PMID 36050763, PMID 38388874)
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Cardioprotection resulting from glucagon-like peptide-1 administration involves shifting metabolic substrate utilization to increase energy efficiency in the rat heart
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