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2018;doi:10.1136/bmjdrc-2017-000456

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2.3 Lipid peroxide accumulation Polyunsaturated fatty acids (PUFAs), which are major constituents of organelle membrane phospholipids, are particularly prone to peroxidation during ferroptosis (Han et al., 2025)

Patients whose primary goal is maximum weight loss and who want the drug with the strongest efficacy data Those who have plateaued on semaglutide and need a more potent treatment Adults with obesity and obstructive sleep apnea (the only FDA-approved pharmacotherapy for OSA) Type 2 diabetes patients who need stronger HbA1c reduction beyond what semaglutide can provide Patients for whom insurance covers tirzepatide at comparable or lower cost to semaglutide Who should choose semaglutide