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The reduction of Ub is a signal of improved cell homeostasis, which implies a reduced protein degradation caused by the stress response

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Neurosci Biobehav Rev 149:105159 Morshed ASM, Noor T, Uddin Ahmed MA, Mili FS, Ikram S, Rahman M et al (2023) Understanding the impact of acne vulgaris and associated psychological distress on self-esteem and quality of life via regression modeling with CADI, DLQI, and WHOQoL