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Moreover, testicular benefits with SGLT2i treatment were demonstrated in leptin receptor-deficient diabetic mice, where the administration of dapagliflozin improved seminiferous tubule destruction, increased sperm concentrations and motility and protected testicular cells from apoptosis, increasing B-cell leukemia/lymphoma 2 protein and X-linked inhibitor of apoptosis protein, and oxidative stress, through the increase of superoxide dismutase and glutathione peroxidase activity [165]

Losing weight is also advised for those who are overweight

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This creates a strong incentive to maintain treatment, even in the face of inconvenience or mild side effects

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