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And, as we do not yet understand the mechanism behind semaglutide's impact on cardiovascular disease, researchers have called for caution when it comes to widespread prescription of this medication for purposes beyond weight loss and diabetes management

Overall, preclinical studies have shown that GLP-1RA reduces alcohol consumption, reduces motivation to drink alcohol, and prevents alcohol relapse, potentially reducing alcohol-induced reward [91]

Next, we will discuss the role of exploring the link between obesity, insulin resistance, and gut microbiome in metabolic dysfunction

Inder WJ, Meyer C, Hunt PJ

and detail the preventive and therapeutic advances in animal experiments, clinical trials, and clinical experience