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Analysis of over 11,000 participants in the SUSTAIN and PIONEER trials revealed that gastrointestinal disorders were the predominant adverse effects, occurring in approximately 39-42% of semaglutide users compared to 22-25% of those receiving comparators

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Because of this (long) half-life, semaglutide is usually given as a once-weekly injection, which helps maintain a steady level in your system over time

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