A mechanism of action phase 1 study showed that the glycemic efficacy of tirzepatide in T2DM results from concurrent improvements in key components of diabetes pathophysiology, including -cell function, insulin sensitivity, and glucagon secretion (135)
Your cells may be asking for antioxidant backup
66 (Tables 1 and 2) Current GLP-1RAs GLP-1RAs are synthetic protein preparations that have partial or complete amino acid sequence homology with GLP-1 found in the body, are not easily degraded, have longer half-lives and have stronger biological activity
Switching to coffee with meals, adding plant-based milk or a small amount of protein, or reducing caffeine intake often resolves the issue within days
This framing is uncomfortable for many people who view medication as something you take temporarily until a problem resolves, but it aligns with the biological reality of obesity as a chronic disease with chronic neurohormonal underpinnings