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Clinical trials have documented gastrointestinal side effects (nausea, constipation, abdominal pain) in a significant proportion of patients, and these symptoms may occasionally manifest as referred pain to the back region
Weight loss is the most visible change, with clinical trials demonstrating average reductions that vary by medication: approximately 5-10% with liraglutide (Saxenda), 15-17% with semaglutide 2.4mg (Wegovy) in the STEP trials, and up to 20% with higher doses of tirzepatide in the SURMOUNT programme
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