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Semaglutide Significantly Reduces Risk of Renal Events, MACE, Mortality in People with CKD, T2D in Final FLOW Trial Findings Grace Halsey The pluripotent GLP-1 mimetic reduced risk for renal disease endpoints by 24% and MACE by 18% plus significantly retarded decline in eGFR vs placebo, study authors reported
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Patients with Type 2 diabetes have many other drug treatment options, including other GLP-1 receptor agonists like Mounjaro (tirzepatide) and Trulicity (dulaglitude)
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Potential mechanisms linking both are impaired dopamine signaling and inflammation (also see below), which both alter reward sensitivity and have been shown to be altered in DM2 and anhedonia [120]
