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Another interesting mechanism of the antioxidant effect of GSH may lay via the activation of cardiac uncoupling proteins (UCPs) (Figure 3A) that mediate H + -leak from intramembrane space of mitochondria into the matrix regulating ATP production via so-called mild uncoupling ( 2 production by the electron transport chain, thus, UCPs are considered protective proteins against oxidative stress (Zhou et al., 2000
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Previous research indicates that binary solvent systems, when optimized for composition, can significantly outperform single solvents in dissolving active pharmaceutical ingredients (APIs) 24,25,26
