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In STEP 1 [1] , the largest trial with 1,961 participants [1] , patients receiving semaglutide 2.4 mg weekly achieved an average weight loss of 14.9% over 68 weeks, compared to 2.4% with placebo (Wilding et al., NEJM, 2021)
Smaller droplets risk inhalation into the lungs
The drug continues to be a blockbuster for Regeneron as it brought in $9.65 billion for Regeneron in 2022
Inflammation in obesity-related HFpEF: the STEPHFpEF program
However, there are examples of drugs being withdrawn from the market as more long-term data comes to light
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