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The goal is progressive loading that stimulates further tissue adaptation without exceeding the healing tissues capacity

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A population-based study has shown that sperm motility and forward movement are significantly decreased in heavy smokers compared to non-smokers, and oxidative stress and iron levels are elevated [82]

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This is the most telling comparison, because it comes from a single study (REDEFINE 1), in which all three arms were assessed in parallel and it shows the additive effect of two pathways