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Henmi H, Endo T, Kitajima Y, Manase K, Hata H, Kudo R

Recent studies in aged mice show improved muscle endurance and recovery, mimicking exercise benefits.[14] This evolution positions 5-Amino-1MQ as a multi-faceted tool, not just for weight but for systemic anti-aging

This yields the active dimeric enzyme structure

These include modulation of inflammatory mediators (chemical messengers that drive swelling and pain), support of angiogenesis (formation of new small blood vessels that deliver oxygen and nutrients), and interactions with nitric oxide signaling (a pathway involved in blood flow and cellular communication)

doi: 10.3389/fnins.2026.1731771 Received 24 October 2025 Revised 19 January 2026 Accepted 21 January 2026 Published 03 February 2026 Volume 20 - 2026 Edited by Heather Jane Mortiboys, The University of Sheffield, United Kingdom Reviewed by Abhishek Balmik, Emory University, United States Avital Schurr, University of Louisville, United States Updates Copyright 2026 Pang, Yang, Liu, Xie and Wang