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A companion mechanistic paper, Chang et al., Molecules 2014, found that the peptide up-regulated growth-hormone-receptor expression in tendon fibroblasts at both mRNA and protein levels, potentially sensitising these cells to growth hormone during repair

Overdoing it can occasionally lead to side effects like nerve irritation (with too much B6), skin flushing (from high-dose B3), or digestive upset

Ismail, David W