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Its history began with a breakthrough by a research team at the University of Texas, USA, in 2017.At that time, NNMT was recognized as a key enzyme in cellular metabolism and energy homeostasis, highly active in adipose tissue and closely linked to obesity, type 2 diabetes, and other metabolic diseases
38 (1), e23543
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Clinical studies have documented modest reductions in fasting glucose, HbA1c, and LDL cholesterol with oral supplementation, though effect sizes are generally smaller and evidence quality more variable than for conventional pharmaceutical agents like metformin
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