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Weight loss for obese patients as a treatment of hip and knee osteoarthritis: A scoping review

Key findings: Pharmacokinetics were dose proportional Steady-state exposures were maintained with once-weekly dosing Body weight reduction was dose-dependent: up to -8.96 kg in the highest dose group vs placebo at 12 weeks HbA1c reductions of -0.4% to -1.2% across dose groups Safety profile consistent with other incretin drugs (GI adverse events most common) Drug Interactions and Kidney Function: What Has Been Studied oral drug taken alongside it

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10.1002/dmrr.1202 7 Aschebrook-KilfoyB.SabraM