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(38) found that at nutritionally relevant concentrations, oleuropein and hydroxytyrosol, among all the tested molecules present in olive oil and red wine, reduced monocytoid cell adhesion to stimulated endothelium, as well as vascular cell adhesion molecule-1 (VCAM-1) mRNA and protein in human umbilical vein endothelial cells incubated for 30 min with the phytochemicals, followed by co-incubation with bacterial lipopolysaccharide or cytokines to trigger adhesion molecule expression

It is important to understand that the key players evaluating their novel therapies in the pivotal and confirmatory trials should remain vigilant when selecting appropriate comparators to stand the greatest chance of a positive opinion from regulatory bodies, leading to approval, smooth launch, and rapid uptake

13 These findings suggest that supporting gut health with probiotics, prebiotics, and fiber may indirectly enhance GLP-1 activity and overall metabolic function

10.2337/db09-1694

[PMID: 8753465] PubMed record related to this compound for laboratory literature review