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Lets rewinds and introduce the background biology
The juxta-epithelial region shows the presence of diffuse melanin pigmentation along with the presence of melanocytes and melanophages (macrophages that engulf the melanin pigment)
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The in vivo study utilized naturally aged male C57BL/6 mice between 20-24 months old and young adult male C57BL/6 mice that were 3 months old
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