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Pregnancy, Surgical Planning, and Other Contraindications Both semaglutide and tirzepatide are contraindicated during pregnancy
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Specifically, the combination of MCT4 inhibition with ferroptosis inducers not only depletes lactate accumulation but also enhances CD8+ T cell infiltration and ferroptosis-driven ICD, thereby synergistically improving checkpoint blockade efficacy (111)
Kohli, S
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