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Available from: National Institutes of Health, Office of Dietary Supplements

10.1021/acschemneuro.4c00620 65 LiangD.FengY.ZandkarimiF.WangH.ZhangZ.KimJ.et al (2023)

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That does not mean every study will show the same pattern, but it does explain why dose escalation and tolerability are often discussed together

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