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Human Evidence (Limited but Promising) The most clinically relevant data comes from a 2016 study by Choi et al

GLP-1 RAs reduced the risk of progression to ESKD in lupus nephritis patients by lowering pro-inflammatory mediators

Weight loss results at 48 weeks: Weight loss at 24 weeks (the primary endpoint, combined dose groups): Most of the dose separation was already visible by 24 weeks and participants on the higher doses were still losing weight at 48 weeks, with no clear plateau

The patient-friendly bottom line Many people can use GLP-1 drugs safely

Anti-obesity medications or medications to treat obesity instead of weight loss drugs why language matters an official statement of the Brazilian Association for the Study of Obesity and Metabolic Syndrome (ABESO) and the Brazilian Society of Endocrinology and Metabolism (SBEM)