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(ii) evidence for S -glutathionylation in protein modulation and apoptotic initiation

NRF2-driven anti-inflammatory pathway in astrocytes has also been shown to be regulated by sirtuin-1 deacetylase (SIRT1) in vitro and in an EAE model (131)

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Seiwerth and colleagues (Inflammopharmacology, 1999) documented effects on angiogenic growth factor pathway signalling, and subsequent work has expanded characterisation to include VEGF receptor 2 upregulation, endothelial cell migration in capillary-formation assays, and improved healing in ischemia-reperfusion preparations