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When your stomach is distended, especially for a long time, it increases the likelihood of stomach acid escaping back up into your esophagus, says Weisenberger
Such an increase can be drastic up to hundreds of thousands of dollars or more just for these medications
One study found that over 90% of GLP1 users failed to meet requirements for Vitamin D, potassium and choline (Spreckley 2026)
People with a BMI below 27 need further clinical evaluation to determine if a GLP-1 medication is appropriate for them
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![Physiologic effects of GLP-1 (adapted from Granata et al. [11])](https://www.researchgate.net/publication/359199250/figure/fig1/AS:11431281081130351@1661532031197/Physiologic-effects-of-GLP-1-adapted-from-Granata-et-al-11.png)
