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Step 1: Exposure to UV radiation generates Reactive Oxygen Species (ROS) [3] Step 2: High levels of ROS induce oxidative stress, which leads to Tyrosinase activation, the enzyme responsible for melanin synthesis
Paradoxically, this same mechanism may underlie its potential pro-cancer effects: by boosting GSH production, cancer cells can better protect themselves from oxidative damage caused by ROS (Ramachandran and Jaeschke, 2021)
On treatment with a bolus of H 2 O 2 (500 M) to induce oxidative stress, the ratiometric imaging of HeLa cells revealed a decrease in the GSH level from 5.0 to 4.1 mM within 90 s (Fig
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The study evaluated cell survival rates and protein levels using the MTT test and western blot analysis
