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Serum folate and risk of fatal coronary heart disease
You might think that would at least coincide with a superior safety profile, but that same study saw a greater rate of trial discontinuation due to adverse effects in the liraglutide group than in the semaglutide group.7 It also requires daily dosing, which is less convenient than the weekly administration of semaglutide and tirzepatide
This compound modulates macrophage and DC functions, induces CD4+ and CD25+ T cells, and stimulates the development of Th2 cells
Gradual dose escalation and supportive measures can help minimise these effects
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