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Tirzepatides insulinotropic effects on human islets depend on GIPR activity, according to Ei et al

These findings, together with the convenience of oncedaily oral dosing and onceweekly injection, support the use of these medications in this prediabetic population. Karen Elkind-Hirsch Elkind-Hirsch and colleagues recruited 119 premenopausal women aged 18 to 45 years with obesity and PCOS and without diabetes to participate in the study

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When pain medications are used repeatedly, foundational nutrients are gradually depletedoften without obvious early symptoms

10.1016/j.ccell.2025.05.011 Cancer Cell