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T o find a group of people w h o had lived in isolation for an estimated 2,000 years was so unusual that care was taken to preserve the separation of the tribe from the remainder of society lest some contami- nation destroy the uniqueness of their situation

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Across GLP-1 trials, about 60% of lost weight returns within the first year and roughly 75% returns over the longer curve, with the fastest regain in the early months. The semaglutide extension follows the same direction. The pattern reflects removal of appetite suppression after major weight loss