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Transdermal absorption of large molecules is governed by skin barrier physics, not sex hormones, and the barrier constraint applies identically

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Of those molecules that appear to be progressing well, Dapagliflozin, developed by Bristol-Myers Squibb and AstraZeneca Ltd, is currently in Phase 3 and is an inhibitor of SGLT2, which in turn impedes glucose reabsorption in the proximal tubule leading to glucosuria and plasma glucose reduction (Figure 1)

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