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16 A sub-study of the SURPASS-3 trial on overweight/obese patients with T2DM demonstrated that tirzepatide decreased liver fat by 8.1% over 52 weeks, along with significant reductions in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (NCT03882970), 17 indicating that tirzepatide may improve liver steatosis or inflammation

Potential Indirect Causes of Dysuria Related to Semaglutide Although semaglutide itself does not seem to cause painful urination, there are indirect ways it might influence symptoms related to urination

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Common mild side effects may include: Nausea or slight stomach discomfort (usually temporary) Fatigue or mild dizziness during the adjustment phase Reduced appetite or altered taste preferences Most patients report that these effects diminish within the first few weeks as their bodies adapt