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This exploratory, cross-sectional finding suggests a distinct role of oxidative stress in migraine pathophysiology

Excess acetaldehyde increases homocysteine (Hcy) conversion to methionine but reduces glutathione (GSH), allowing ROS to damage liver cells and raise GGT levels

pii Mihalj M, Tadzic R, Vcev A, Rucevic S, Drenjancevic I

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We have solved the structures of the pi class GST hP1-1 in complex with its substrate, glutathione, a transition-state complex, the Meisenheimer complex, and an inhibitor, S-(rho-bromobenzyl)-glutathione, and refined them to resolutions of 1.8 A, 2.0 A and 1.9 A, respectively