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In this regard, restoring the basement membrane and preventing the release of melanocytes and melanin into the dermis layer would be essential for long-term treatment of melasma

Horm Res Paediatr (2016) 85(2):1406

The Tim-3/Gal-9 pathway also inhibits the function of macrophages and downregulates the release of inflammatory factors

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10 Solar keratoses appear as multiple, pink-red flat spots (Figure 3), or skin coloured, rough, scaly spots (Figure 4)