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MRT for the marker compounds viz, diosgenin, charantin, and hydroxychalcone was found to be 8.20 and 9.94 h, 14.75 and 11.98 h, and 7.87 and 7.90 h for i.v
They therefore manipulated two enzymes called proprotein convertase 2 (PC2), which is responsible for boosting glucagon production, and proprotein convertase 1 (PC1), a producer of GLP-1 in intestinal cells and pancreatic alpha cells
These non-selective effects create cardiovascular stress and uncomfortable side effects
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