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It is critical for T cell metabolism and function [130], and can be degraded into different molecules, such as indole-propionic acid (IPA), indole-3-acetic acid (IAA), and trans-3-indoleacrylic acid by microorganisms, or kynurenine by our own cells (expressing the enzymes indoleamine dioxygenase 1-IDO1-, IDO2, and Tryptophan 2,3-dioxygenase- TDO2)

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