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Who benefits most from microdosing: Patients with a history of severe nausea on other GLP-1 agonists (semaglutide, liraglutide) Patients with baseline gastroparesis, GERD, or functional dyspepsia Older adults (65+) who metabolize peptides more slowly Patients on medications that slow gastric emptying (opioids, tricyclic antidepressants, anticholinergics) Patients who cannot afford to miss work due to GI side effects during the first two weeks Microdosing is not necessary for most patients