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In parallel with the human studies, preclinical and in vitro pharmacological work has played a crucial role in understanding of the physiological and pathophysiological role of endogenous GIP and the potential of GIP receptor antagonism as a therapeutic concept

Stress, fatigue, loneliness, and sudden changes in routine can all drive individuals toward food for comfort or distraction

Importantly, orlistat is contraindicated in patients with chronic malabsorption syndrome and cholestasis [65], conditions that require avoidance of fatty foods

The most reliable and easy rule is: Eat your goal weight in grams of protein per day

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