Preparations that cause more moderate, sustained slowing rather than pronounced acute effects may be better tolerated
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The Cardiovascular Effects of Cocoa Polyphenols-An Overview
So were talking about anecdotes, social media posts, unpublished observations
In PTZs, substitutions at the C-10 position, such as alkyl or aryl groups, reduce activity, whereas modifications at the C-2 position significantly enhance potency, such as featuring a 2-phenyl-methyl piperazine at C-2, which demonstrated remarkable activity with an EC50 of 0.5 nM in erastin-induced ferroptosis in HT-1080 cells (Yang et al., 2021)