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However, persistent staining suggests a product quality issue

Daytime splinting during high-risk activities (driving, computer work, tool use) if symptoms are activity-triggered

Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1 SU)

Do not use if you or a family member has medullary thyroid carcinoma (MTC) or MEN2

The goal is to keep it below 25% of total weight lost, which is the threshold where cardiometabolic benefits remain largely preserved