GLP-1RAs reduce risks of neurocognitive, substance use, cardiovascular and respiratory disorders, but increase risks of gastrointestinal issues, hypotension and pancreatitis
It is important to stay on a very repetitive weekly schedule
Tirzepatide does not directly worsen celiac disease, but its gastrointestinal side effects (nausea, diarrhea, abdominal discomfort) may overlap with celiac symptoms, particularly in patients with active disease or incomplete mucosal healing
It only makes the work slightly easier, and once people see that, many stop seeing the point of paying for it at all
Trial data suggest that 8 mg and 12 mg weekly are among the most effective studied maintenance ranges, but future regulatory guidance will determine how it may eventually be prescribed