In posterior segments of the gut (e.g., the cecum and proximal large intestine), gut microbes directly cleave the CN bond of carnitine to release TMA, which subsequently enters the liver through the portal circulation, is converted to TMAO by hepatic flavin monooxygenases (FMOs) [242, 243], and eventually enters the blood circulation [244]
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Zepbound and other weight loss drugs typically used to treat diabetes mimic hormones that regulate hunger and satiety, helping people feel full sooner and eat less, according to a University of Chicago Medicine report in June