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NNMT expression is significantly upregulated in white adipose tissue during obesity (3-5 fold) and increases with age across multiple tissues, creating a metabolic drain on both the NAD+ pool and the methylation budget
This reduction in melanin leads to the loss of hair colour
Greenwood-Van Meerveld et al., "Efficacy of ipamorelin, a ghrelin mimetic, on gastric dysmotility in a rodent model of postoperative ileus," J
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