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Phase 2 clinical trials of retatrutide, including the landmark studies published in the New England Journal of Medicine in 2023, primarily evaluated the drug's efficacy and safety in terms of weight reduction, cardiovascular markers, and gastrointestinal tolerability

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And reduction rate between (-5.6,-6.7 mm Hg) in a 26 week study of liraglutide in combination with Metformin and Rosiglitazone compared to (-1.1 mm Hg)placebo and also with no difference in diastolic blood pressure [12]

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Furthermore, research has shown that eating red meat significantly raises TMAO levels