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These immune-mediated events were compounded by intolerable gastrointestinal side effects, including nausea in 59% and vomiting in 37% of participants, along with reports of acute pancreatitis, culminating in a dropout rate of 2634% in Phase 3 trials [65]

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As drug prices rise due to inflation-driven manufacturing and distribution costs, patients may delay or forgo treatment, especially in markets with limited insurance coverage