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The following groups have typically been excluded from clinical trials or would require careful specialist assessment, reflecting cautions seen across related approved medicines: A personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2): This is a theoretical concern that has led to exclusion from trials of GLP-1 receptor agonist therapies, based on animal data
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NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis
It also keeps commercial intent safe by focusing on verifiable records
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